Base game
- Platinum Trophy All Trophies obtained! 25%Rare
- Museum Master Complete "The Museum" Level as Megamind 86.9%Common
- Downtown Domination Complete "Downtown" Level as Megamind 78.7%Common
- Destruction Doom Complete "Demolition Site" Level as Megamind 71.7%Common
- Tickets Please Complete "The Underground" Level as Megamind 64.6%Common
- Funky Fumes Complete "The Sewers" Level as Megamind 56.6%Common
- Funky Disco Complete "Funky Disco" Level as Megamind 53.7%Common
- Uptown Hero Complete "Uptown" Level as Megamind 52%Common
- Hot Pavement Complete "The Overpass" Level as Megamind 50.7%Common
- Hot Flash Fizzle Complete "The Parklands" Level as Megamind 49.4%Rare
- Tame Blue Tighten Complete "Blue Tighten Battle" Level as Megamind 49%Rare
- Destruction Derby Defeat Destruction Worker without dying as Megamind 41.1%Rare
- Psychotic Win Defeat Psycho Delic without dying as Megamind 29.4%Rare
- Flash in the Pan Defeat Hot Flash without dying as Megamind 37.8%Rare
- Tightanic Battle Defeat Blue Tighten without dying as Megamind 42.8%Rare
- Mega-Hero Complete the Game as Megamind 49%Rare
- Assistant Collector Collect 1000 B.I.N.K.E.Y. in any single level as Megamind 88.1%Common
- Collector Collect 2000 B.I.N.K.E.Y. in any single level as Megamind 82.9%Common
- Mega Collector Collect 3000 B.I.N.K.E.Y. in any single level as Megamind 75.1%Common
- Lair Clean Up Collect 150 B.I.N.K.E.Y. in the Lair as Megamind 77.9%Common
- Mega-Skill Complete any story mission without dying as Megamind 64.2%Common
- Mega-Ball Unlock the Mega-Ball mini-game as Megamind 64.6%Common
- Pod Race Unlock the Pod Race mini-game as Megamind 78.7%Common
- Sticky Boots Unlock the Sticky Boots mini-game as Megamind 50.7%Common
- Rampage Unlock the Rampage mini-game as Megamind 56.6%Common
- Mega-Blast Unlock the Mega-Blast mini-game as Megamind 52%Common
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.