Base game
- Platinum Trophy Unlock all trophies 1.9%Ultra rare
- Warming Up! Finish the game on Normal Mode 15.4%Rare
- Boiling!! Finish the Game on Hard Mode 3.3%Ultra rare
- Combustible!!! Finish the game on Dante Must Die Mode 2.2%Ultra rare
- The Devil's In The Details Purchase all of Dante's Skills 5.2%Very rare
- Can You Keep A Secret? Complete a Secret Mission 24.1%Rare
- The Secret Six Complete six Secret Missions 4%Ultra rare
- The Secret's Out Complete all Secret Missions 3.1%Ultra rare
- Smashing Sensation Achieve an S Rank on any Mission 20.1%Rare
- Arachnophobia Survive an encounter with Phantom 48.6%Rare
- You're No Angel Survive an encounter with Nelo Angelo 40.2%Rare
- Squashed Like A Bug Defeat Phantom 33.6%Rare
- Bird of Prey Survive an encounter with Griffon 32.2%Rare
- Broken Halo Fight Nelo Angelo a second time and prevail 30.3%Rare
- Cold Turkey Fight Griffon a second time and prevail 29.2%Rare
- Plucked Defeat Griffon 27.6%Rare
- Night Terrors Survive an encounter with Nightmare 26%Rare
- Fallen Angel Defeat Nelo Angelo 24.7%Rare
- Good Night Fight Nightmare a second time and prevail 24%Rare
- The Nightmare is Over Defeat Nightmare 22.6%Rare
- The Devil Went Down To... Defeat Mundus 21.1%Rare
- Thunderstruck Perform an S Rank Combo using Alastor 38.9%Rare
- Hot As Hell Perform an S Rank Combo using Ifrit 25.2%Rare
- Table Of Contents Unlock every enemy file in the status menu 16.7%Rare
- Bookworm Unlock 50% of all entries for every enemy file in the status menu 30.3%Rare
- I Read You Like A Book Unlock all the entries for every enemy file in the status menu 2.1%Ultra rare
- Seeing Red Collect 10,000 Red Orbs 29.6%Rare
- Blood Flows Red Collect 25,000 Red Orbs 18.4%Rare
- Redemption Collect 50,000 Red Orbs 5.5%Very rare
- Blue Demon Complete a Blue Orb 52.6%Common
- Blue Devil Max out the Health Bar 2.7%Ultra rare
- Gun Collector Collect all Guns 23.1%Rare
- The Devil Made Me Do It Finish the game without using any Yellow Orbs 4%Ultra rare
- Untouchable Clear a mission without taking damage 12.3%Very rare
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.