Base game
- The House of the Dead: Overlord Unlock all trophies 1.2%Ultra rare
- Papa's Palace of Pain Complete "Papa's Palace of Pain" in Story Mode 62.4%Common
- Naked Terror Complete "Naked Terror" in Story Mode 46.5%Rare
- Ballistic Trauma Complete "Ballistic Trauma" in Story Mode 40.1%Rare
- Carny Complete "Carny" in Story Mode 35.8%Rare
- Creeping Flesh Complete "Creeping Flesh" in Story Mode 32.3%Rare
- Scream Train Complete "Scream Train" in Story Mode 30.2%Rare
- The Fetid Waters Complete "The Fetid Waters" in Story Mode 28.2%Rare
- Jailhouse Judgment Complete "Jailhouse Judgment" in Story Mode 26.6%Rare
- Overkill Complete all levels in Story Mode 22.5%Rare
- Goregasm! Achieve a Goregasm 13.2%Very rare
- Weak At The Knees Maintain a Goregasm for 2 minutes 5.9%Very rare
- De-Generation Collect 10 LPs 21.2%Rare
- Decom-Poster Child Collect 15 posters 14%Very rare
- Dis-Figurine Collection Collect 15 figurines 24.1%Rare
- Graphic Horror Collect 17 comic book pages 11%Very rare
- Boom Headshot! Decapitate 200 mutants 34.1%Rare
- Toasty! Kill 5 or more mutants with one grenade 28.9%Rare
- Yakuza Kill 100 mutants "Gangster Style" (holding gun sideways) 7.1%Very rare
- Suffer Like G Did Complete any level with only one health segment remaining 31.8%Rare
- Hardcore Complete any level in Director's Cut without using any continues 13%Very rare
- Merchant of Menace Buy a new weapon 30.9%Rare
- Fully Loaded Fully upgrade any weapon 17%Rare
- Power of the Mind Complete any level with the targeting crosshair off 4.3%Ultra rare
- I'll Try Anything Once Play each minigame through to completion once 18.7%Rare
- Lights, Camera, Headshot! Complete all levels in Director's Cut 6.5%Very rare
- Caesar's Salad Complete all CHALLENGES for "Papa's Palace of Pain" 1.5%Ultra rare
- Private Dance Complete all CHALLENGES for "Naked Terror" 1.5%Ultra rare
- Doctors and Nurses Complete all CHALLENGES for "Ballistic Trauma" 1.4%Ultra rare
- Clown Shoes Complete all CHALLENGES for "Carny" 1.3%Ultra rare
- Meat Packer Complete all CHALLENGES for "Creeping Flesh" 1.4%Ultra rare
- Bad Conductor Complete all CHALLENGES for "Scream Train" 1.4%Ultra rare
- Swamp Monster Complete all CHALLENGES for "The Fetid Waters" 1.3%Ultra rare
- Jail Bird Complete all CHALLENGES for "Jailhouse Judgment" 1.3%Ultra rare
- Lab Rat Complete all CHALLENGES for "Overkill" 1.3%Ultra rare
- Never Runs Dry Complete a level without triggering an enforced reload (i.e. reaching zero bullets) 9.2%Very rare
- Be My Valentine, Jill Unlock all unlockables and purchase all weapons 1.4%Ultra rare
- Perfect Victory Achieve an S rank for all levels in Story Mode or Director's Cut 1.3%Ultra rare
- Do You Feel Lucky? Complete all levels in Classic Mode without using any continues 1.5%Ultra rare
- Extreme Hardcore Complete all Director's Cut levels in Hardcore Mode 1.8%Ultra rare
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.