3 trophies of this game can no longer be earned.
Five secrets pertaining to unlocking challenges don't unlock in the secrets menu, making these trophies impossible to obtain:
Source of part of this data: PSNP+
Base game
- Platinum Obtain all trophies Can no longer be earned 2.7%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 17.7%Rare
- Secret trophy Its name and description stay hidden until you earn it. 19.2%Rare
- Secret trophy Its name and description stay hidden until you earn it. 6.3%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 5.9%Very rare
- Magdalene Have 7 or more max red hearts at one time 43.7%Rare
- Secret trophy Its name and description stay hidden until you earn it. 12.2%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 12%Very rare
- Cain Hold 55 or more pennies at one time 41.9%Rare
- Secret trophy Its name and description stay hidden until you earn it. 13.5%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 13.8%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 27.7%Rare
- Secret trophy Its name and description stay hidden until you earn it. 13.5%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 13.7%Very rare
- Eve Beat 2 levels in a row without picking up any hearts 42.4%Rare
- Secret trophy Its name and description stay hidden until you earn it. 10.7%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 10.5%Very rare
- Samson Beat 2 levels in a row without taking damage 33.3%Rare
- Secret trophy Its name and description stay hidden until you earn it. 12.6%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 12.4%Very rare
- Azazel Make 3 deals with the devil in one run 45.6%Rare
- Secret trophy Its name and description stay hidden until you earn it. 19.5%Rare
- Secret trophy Its name and description stay hidden until you earn it. 22.6%Rare
- Lazarus Have 4 or more soul hearts at one time 55.4%Common
- Secret trophy Its name and description stay hidden until you earn it. 11.4%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 11.2%Very rare
- Eden Beat the Womb for the first time 36.9%Rare
- Secret trophy Its name and description stay hidden until you earn it. 13.9%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 13.2%Very rare
- Something from the future Beat the Basement 40 times 28.5%Rare
- Something Cute Beat the Caves 30 times 23.4%Rare
- Something sticky Beat the Depths 20 times 23.2%Rare
- Basement Boy Beat the Basement/Cellar without taking damage 34.7%Rare
- Spelunker Boy Beat the Caves/Catacombs without taking damage 17.5%Rare
- Dark Boy Beat the Depths/Necropolis without taking damage 14.8%Very rare
- Mama's Boy Beat the Womb/Utero without taking damage 16.5%Rare
- Secret trophy Its name and description stay hidden until you earn it. 11.5%Very rare
- Challenges Beat all 20 Challenges 4.1%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 27.9%Rare
- Secret trophy Its name and description stay hidden until you earn it. 16.6%Rare
- Secret trophy Its name and description stay hidden until you earn it. 17%Rare
- Secret trophy Its name and description stay hidden until you earn it. 13.3%Very rare
- Little Baggy Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball 40.2%Rare
- The Womb Kill Mom 49.2%Rare
- The Halo Kill Mom using the Bible 21.5%Rare
- Transcendence Kill Mom's Heart 3 times 30%Rare
- Everything Is Terrible Kill Mom's Heart 5 times 26.8%Rare
- A Quarter Kill Mom's Heart 8 times 23.7%Rare
- A Fetus In A Jar Kill Mom's Heart 9 times 23.1%Rare
- Blue Baby Kill Mom's Heart 10 times 22.4%Rare
- It Lives Kill Mom's Heart 11 times 21.9%Rare
- Secret trophy Its name and description stay hidden until you earn it. 9.5%Very rare
- The Book Of Sin Kill all 7 sins 38.7%Rare
- Secret trophy Its name and description stay hidden until you earn it. 17.8%Rare
- Secret trophy Its name and description stay hidden until you earn it. 17.8%Rare
- Golden God You are the best! 15%Very rare
- Platinum God Collect all items and unlock all secrets and endings Can no longer be earned 3%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 9.2%Very rare
- Secret trophy Its name and description stay hidden until you earn it. Can no longer be earned 2.9%Ultra rare
The Binding of Isaac: Afterbirth
DLC- Lilith Beat Greed Mode with Azazel 13.2%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 5.5%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 4.9%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 5.1%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 3.7%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 3.4%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 4.3%Ultra rare
The Binding of Isaac: Afterbirth+
DLC- Secret trophy Its name and description stay hidden until you earn it. 3.5%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 3%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 2.4%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 8.9%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 7.9%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 3.5%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 2.6%Ultra rare
The Binding of Isaac: Repentance
DLC- A Secret Exit Complete ??? 3 times 4.8%Ultra rare
- Bethany Beat Hard mode as Lazarus without losing a life 4.8%Ultra rare
- Jacob & Esau You are just like your father... 4.1%Ultra rare
- Red Key The other side is calling... 4%Ultra rare
- Mega Mush Beat everything in Hard Mode as every character 0.7%Ultra rare
- Death Certificate . . . 0.4%Ultra rare
- Secret trophy Its name and description stay hidden until you earn it. 0.3%Ultra rare
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.