Base game
- Platinum Trophy Acquire all trophies. 8.9%Very rare
- Twenty Questions Twenty questions - well done! 81.6%Common
- Intern Ten responses revealed! 83.9%Common
- Movie Length Two hours played. 53.1%Common
- Mind Games Fifty insanity points reached. 53.8%Common
- Century One hundred questions asked! 67.5%Common
- House Officer One hundred responses revealed! 66.2%Common
- Slightly Mad Two hundred insanity points reached. 38.1%Rare
- Curious Two hundred and fifty questions asked! 51.5%Common
- Registrar Two hundred and fifty responses revealed! 49.9%Rare
- Part Timer Four hours played. 42.3%Rare
- Seeing Things Three hundred insanity points reached. 20.9%Rare
- Committed Five hundred questions asked! 41.9%Rare
- Hinty Aftertaste Solved the case using less than a hundred hints. 31.4%Rare
- Inquisitive One thousand questions asked! 15.2%Rare
- Practitioner Five hundred responses revealed! 40.5%Rare
- Late Shift Eight hours played. 20.7%Rare
- Youthulhu Four hundred insanity points reached. 9.6%Very rare
- The Power of Deduction Solved Doctor Dekker's murder. 34.3%Rare
- Lucky Guess Solved Doctor Dekker's murder without accusing any innocent people. 18.2%Rare
- Cher This You made Nathan sing a song. 14.9%Very rare
- Hintless Wonder Zero hints, and you absolutely didn't cheat at all. 11.1%Very rare
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.