Base game
- Physician Complete The Tutorial 88.8%Common
- Gloucestershire Unlock The Breakfast Room 81.3%Common
- The Chantry Unlock The Dining Room 76%Common
- Smallpox Unlock The Breakfast Room Shutters 72.1%Common
- Experiments Unlock The Library 62.3%Common
- Ridicule Unlock The Dressing Room 63.4%Common
- James Phipps Unlock The Library Shutters 57.7%Common
- Inoculation Unlock Dr. Jenner's Room 52.5%Common
- Napoleonic Wars Unlock Captain Jenner's Room 54.9%Common
- Legacy Unlock The Drawing Room 47.2%Rare
- Entertainer Unlock The Front Door 46.6%Rare
- Letters Find All Correspondance 35.4%Rare
- Vaccinated Complete The Game 46.5%Rare
- Secret trophy Its name and description stay hidden until you earn it. 50.3%Common
- Secret trophy Its name and description stay hidden until you earn it. 68.7%Common
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.