Base game
- The House Of The Dead Unlock all trophies of The House Of The Dead! 5.4%Very rare
- Agent Finish the campaign at any difficulty. 45.7%Rare
- Blood Bath Finish the campaign at ARCADE difficulty. 11.7%Very rare
- Chariot Beat Chariot at the end of the first chapter. 84%Common
- Hangedman Beat Hangedman at the end of the second chapter. 70.9%Common
- Hermit Beat Hermit at the end of the third chapter. 59.4%Common
- Magician Beat the Magician at the end of the fourth chapter. 45.8%Rare
- Normal ending Finish the game with a final score below 62,000 and the last score digit not equal to zero. 27%Rare
- True ending Complete the game with a total score of over 62,000. 21.8%Rare
- Third ending Finish the game with a final score below 62,000 and the last score digit equal to zero. 24.9%Rare
- Ender Discover all three endings. 10.8%Very rare
- Hero Save a scientist. 91.7%Common
- Saviour Save all the Scientists through the campaign. 11%Very rare
- Murderer Kill a scientist. 83.9%Common
- Psychopath Kill all the Scientists at any chapter. 12.6%Very rare
- Traveller Discover all paths available in the game. 6.1%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 11.1%Very rare
- Collector Collect all items in a single campaign. 5.9%Very rare
- Catch'em All! Collect all creature entries. 13.4%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 10.2%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 10.9%Very rare
- Headhunter Blow off 666 heads! 11.4%Very rare
- Sadist Devastate the opponent's body as much as possible! 36.5%Rare
- Triple-Kill! Kill 3 enemies in a row. 36.8%Rare
- Penta-Kill! Kill 5 enemies in a row. 32.2%Rare
- Butcher Kill 666 enemies. 32.5%Rare
- Secret trophy Its name and description stay hidden until you earn it. 9.6%Very rare
- Dance Macabre Nail down the opponent's head with the Pitter. 10.5%Very rare
- Swifty Shoot down 50 enemy projectiles. 32.3%Rare
- Not this time! Finish a single chapter without taking any damage. 8.6%Very rare
- Invincible! Finish the whole campaign without taking any damage. 6.1%Very rare
- Agent G Finish the full campaign with your friend! 22.6%Rare
- Partner Finish any chapter with help of Player 2. 33.7%Rare
- Reinforcements! Let Player 2 join the game while in a middle of a campaign. 10%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 40.1%Rare
- Who let the dogs out? Knock back the Kenfis 7.2%Very rare
- Ringo Knock up an enemy as high as possible. 7.7%Very rare
- No ammo wasted Finish a chapter without reloading with bullets in the chamber. 9.7%Very rare
- Secret trophy Its name and description stay hidden until you earn it. 27.4%Rare
- Secret trophy Its name and description stay hidden until you earn it. 6.3%Very rare
- Unwinged Shoot all of the Hangedman's Devilions. 26.5%Rare
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.