Base game
- The Inoculator Survive for 5 minutes or more in Arcade Mode 27.5%Rare
- Clean-a-rama Get a combo-pop of 100 or more germs with one shot 29.4%Rare
- Secret trophy Its name and description stay hidden until you earn it. 32.9%Rare
- The Marksman Finish any Puzzle level with a single shot 29.9%Rare
- Germ-a-thon Complete 20 different levels in a single run in Puzzle Mode 31%Rare
- Micro-Cleaner Complete all Story Mode levels 29.9%Rare
- Sound Logic Complete all Puzzle Mode levels 28.9%Rare
- Photo Finish Win the 15th round in a Duel match against “The Germinator” 26.2%Rare
- Oozie Fire 50 germs in a single Story, Duel, or Arcade level 48.3%Rare
- Feverish Cleaning Complete a Story Mode level in under 30 seconds 77.2%Common
- Secret trophy Its name and description stay hidden until you earn it. 31%Rare
- The Germinator Collect all stars in Puzzle and Story Mode 26.3%Rare
Trophy names, descriptions and rarity come from PlayStation. Guides open on their authors' own websites.